川芎救心滴丸对动物实验性心肌缺血的保护作用研究

目的采用多种实验模型评价川芎救心滴丸对大鼠和小鼠实验性心肌缺血的保护作用。方法采用结扎大鼠冠状动脉前降支引起急性实验性心肌缺血模型,观察川芎救心滴丸的抗心肌缺血作用;采用静脉注射高分子右旋糖酐致大鼠高黏滞血症模型,观察川芎救心滴丸的活血作用;采用小鼠注射异丙肾上腺素实验模型,观察川芎救心滴丸的耐缺氧作用。结果与模型组比较,大鼠ig川芎救心滴丸0.32、0.64 g/kg剂量组能明显抑制因冠状动脉前降支结扎引起标准Ⅱ导联心电图ST段的升高,明显缩小心肌梗死范围;0.16、0.32、0.64 g/kg剂量组明显抑制高分子右旋糖酐所致高黏滞血症大鼠全血黏度的升高;与模型组比较,小鼠ig川芎救心滴丸0.46、0.92 g/kg剂量组明显延长注射异丙肾上腺素后小鼠常压缺氧条件下的存活时间。结论川芎救心滴丸具有明显的活血、耐缺氧作用,对实验性心肌缺血有明显的保护作用。

Protection of Chuanxiong Jiuxin Dropping Pill on experimental myocardial ischemia in rats and mice

Objective To evaluate the protective effects of Chuanxiong Jiuxin Dropping Pill on experimental myocardial ischemia in rats and mice using various experimental model. Methods The anti-myocardial ischemia effects of Chuanxiong Jiuxin Dropping Pill were observed using acute experimental myocardial ischemia model rats caused by coronary artery ligation of anterior descending branch. The effects of Chuanxiong Jiuxin Dropping Pill on invigorating the circulation of blood were observed using high blood viscosity model rats induced by intravenous injection of high molecular Dextran. The effects of Chuanxiong Jiuxin Dropping Pill on hypoxia tolerance were observed using the injection of isoproterenol experimental model. Results There was significant difference between the model group and 0.32, 0.64 g/kg Chuanxiong Jiuxin Dropping Pill groups in inhibiting the increase caused by the anterior descending coronary artery ligation induced standard II-lead electrocardiograph ST segment and reducing myocardial infarct size. The 0.16, 0.32, and 0.64 g/kg Chuanxiong Jiuxin Dropping Pill groups could significantly inhibit the increase of whole blood viscosity caused by high blood viscosity model induced by high molecular Dextran. There was significant difference between the model group and 0.46, 0.92 g/kg Chuanxiong Jiuxin Dropping Pill groups in prolonging the survival time of mice under normobaric hypoxia condition after the injection of isoprenaline. Conclusion Chuanxiong Jiuxin Dropping Pill has the obvious effect on invigorating the circulation of blood and hypoxia tolerance, and has a protective effect on experimental myocardial ischemia.