左氧氟沙星胶囊联合癃清片治疗2型糖尿病合并尿路感染的疗效观察

目的观察左氧氟沙星胶囊联合癃清片治疗2型糖尿病合并尿路感染的疗效和安全性。方法选取平邑县人民医院2012年10月-2013年10月住院的2型糖尿病合并尿路感染患者209例，将其随机分为治疗组（105例）和对照组（104例），所有患者根据病情分别选用口服降糖药和（或）胰岛素控制血糖，并根据血糖情况调整降糖方案，使血糖控制理想。对照组患者口服盐酸左氧氟沙星胶囊，2粒／次，2次／d；治疗组在对照组基础上口服癃清片，6片／次，2次／d，两组均治疗7d。观察治疗前后患者的临床症状、尿常规变化和不良反应。结果治疗组和对照组有效率分别为95．2％、76．9％，两组比较差异有统计学意义（P〈0．05）；治疗后，患者尿常规中白细胞和红细胞计数均显著减少，治疗组减少更加明显，差异具有统计‘学意义（P〈0．05）。胃部不适为最常见的不良反应，两组间差异无统计学意义。结论左氧氟沙星胶囊联合癃清片治疗2犁糖尿病合并尿路感染有很好的疗效，治疗过程中的不良反应较少，佰得临床应用。

Clinical observation of Levofloxacin Capsules combined with Longqing Tablets in treatment of type 2 diabetes mellitus with urinary tract infection

Objective To observe the efficacy and safety of Levofloxacin Capsules combined with Longqing Tablets in the treatment of type 2 diabetes mellitus with urinary tract infection. Methods The patients （209 cases） diagnosed with type 2 diabetes mellitus with urinary tract infection in the People＇s Hospital of Pingyi County from October 2012 to October 2013 were randomly divided into treatment （105 cases） and control （104 cases） groups. All the patients were given different oral medications and/or insulin according to their condition to control blood sugar, and the treatment was regulated according to the changes of blood sugar. The patients in the control group were po administered with Levofloxacin Capsules, once 2 capsules, twice daily. The patients in the treatment group were po administered with Longqing Tablets, once 6 pieces, twice daily, and other treatment was the same as the control group. Two groups were treated for 7 d. Clinical symptoms, routine urine changes, and adverse reactions were observed before and after the treatment. Results The efficiency for the patients in both the treatment and control groups was 95.2% and 76.9% with the significant difference （P 〈 0.05）. The white and red blood cells in urine decreased significantly compared with those before the treatment, and the treatment group decreased significantly compared with the control group （P 〈 0.05）. Upset stomach was the most frequent adverse reaction, and there was no significant difference between two groups. Conclusion Levofloxacin Capsules combined with Longqing Tablets has an accurate curative effect on type 2 diabetes mellitus with urinary tract infection with low incidence of adverse drug reactions, which could be used in clinic.