稀有人参皂苷糖苷化合成方法的研究进展

稀有人参皂苷是人参皂苷中一类重要的活性成分,该类化合物具有极强的抗肿瘤活性。其主要通过糖苷化的方法来实现,现有的糖苷化方法主要包括化学合成法、酶解法和微生物转化法。研究表明糖苷化能改变化合物的生物活性、稳定性、水溶性、以及与受体分子的相互识别和结合特性,另外还能降低或除去内源和外源有毒物质的毒性。综述了3类糖苷化方法,并对比总结各个方法的优劣之处,有利于选择出最佳的合成稀有人参皂苷的糖苷化方法,以满足临床和科研等方面的需求。对人参皂苷的糖苷化最新研究进展进行综述,并对糖苷化人参皂苷的发展趋势作了简要的讨论。

Research progress on glycosylation methods of rare ginsenosides

Rare ginsenosides, as a class of important active components of ginsenosides, have strongly potent antitumor effects. Glycosylation is the mainly method to synthesis them. There are three methods for glycosylation, namely chemical synthesis, enzymolysis, and microbial transformation. At the same time, studies have shown that glycosylation could change the biological activity, stability, water solubility, and the mutual recognition and binding property with receptor molecules. It can also reduce or eliminate the toxicity of endogenous and exogenous toxic substances. Three types of glycosylation methods have been summarized, and the pros and cons of each method have been compared and concluded, which help us choose the best glycosylation method for the synthesis of rare ginsenosides in order to meet the needs.of clinical and scientific research. In this paper, the new progress on the glycosylation of rare ginsenosides are summarized, and the trends in the development of glycosylation of ginsenosides in the future are also briefly discussed.