Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum |
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| Authors: | Ayouba Ahidjo Badaut Cyril Kfutwah Anfumbom Cannou Claude Juillerat Alexandre Gangnard Stéphane Behr Charlotte Mercereau-Puijalon Odile Bentley Graham A Barré-Sinoussi Françoise Menu Elisabeth |
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| Institution: | Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75724 Paris Cedex 15, France. ahidjo.ayouba@mpl.ird.fr |
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| Abstract: | Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-alpha stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero. |
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