Comparison of the effects of sodium pentosanpolysulfate and unfractionated heparin on venous thrombosis; an experimental study in rats. |
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| Authors: | J Kiesel G Harbauer E Wenzel G Pindur S Bohnerth |
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| Affiliation: | Department of Clinical Hemostaseologie and Transfusion Medicin, University Homburg, Germany. |
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| Abstract: | Sodium pentosanpolysulfate (Fibrezym) and unfractionated heparin (Liquemin) had significant antithrombotic efficacy in rats. 1 mg/kg body weight (BW) FibrezymR had its maximal effect 2-4 hours after subcutaneous administration; 200 U/kg BW LiqueminR s.c. were most effective 4-6 hours after application. Both drugs caused frequent embolic break-offs of thrombi during the time periods of maximal antithrombotic efficiency. |
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