| 可溶性肿瘤坏死因子Ⅰ型受体在斑秃发病中的作用 |
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| 引用本文： | 许冰. 可溶性肿瘤坏死因子Ⅰ型受体在斑秃发病中的作用[J]. 中国皮肤性病学杂志, 2001, 15(5): 293-294 |
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| 作者姓名： | 许冰 |
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| 作者单位： | ##浙江大学医学院附属第一医院皮肤科 |
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| 摘 要： | 目的：探讨可溶性肿瘤坏死因子Ⅰ型受体（sTNF-RI)与斑秃的关系。方法：应用双抗体夹心ELISA法检测72例斑秃患者及45例正常人血清中sTNF-RI的含量。结果：斑秃患者血清中sTNF-RI水平高于正常人；活动期与稳定期斑秃血清中sTNF-RI水平均较正常明显增高，但活动期与稳定期患者间无明显差异，结论：斑秃患者存在外周血sTNF-RI水平异常变化,sTNF-RI可能参与斑秃的发病。
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| 关 键 词： | 斑秃 受体 肿瘤坏死因子 |
| 文章编号： | 1001-7089(2001)05-0293-02 |
| 修稿时间： | 2000-04-28 |
Role of Soluble Tumor Necrosis Factor Receptor Type I in Alopecia Areata |
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| XU Bing. Role of Soluble Tumor Necrosis Factor Receptor Type I in Alopecia Areata[J]. The Chinese Journal of Dermatovenereology, 2001, 15(5): 293-294 |
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| Authors: | XU Bing |
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| Affiliation: | XU Bing Department of Dermatology,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China |
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| Abstract: | Objective To investigate the relationship between soluble tumor necrosis factor receptor type I(sTNF RI) and alopecia areata(AA).Methods Serum levels of sTNF RI were determined by double antibody sandwich enzyme linked immunosorbent assay(ELISA) in 71 patients with AA and 45 normal controls.Results Serum levels of sTNF RI in patients with AA were significantly higher than those in normal controls( P <0.01);Serum sTNF RI concentrations were found to be significantly elevated in both active AA and stable AA.However,it was not correlated with the activity of the disorder.Conclusion These findings reveal that AA is associated with aberrations in sTNF RI in perpheral blood.The study suggests that sTNF RI may participate in the pathogenesis of AA. |
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| Keywords: | Alopecia areata Receptor Tumor necrosis factor |
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