| VKORC1-1639G／A基因多态性与华法林应用剂量关系的研究 |
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| 引用本文： | 吴小盈,章伟平,陈慧,骆杰伟. VKORC1-1639G／A基因多态性与华法林应用剂量关系的研究[J]. 中华临床医师杂志(电子版), 2008, 2(3): 13-15 |
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| 作者姓名： | 吴小盈 章伟平 陈慧 骆杰伟 |
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| 作者单位： | [1]福建医科大学省立临床医学院心内科,福州350001; [2]福建省立医院中医科,福州350001; |
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| 基金项目： | 福建省青年人才科技创新项目 , 福建省自然科学基金 |
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| 摘 要： | 目的探讨维生素K环氧化物还原酶复合物1基因（VKORC1）-1639G／A多态性对中国汉族人华法林应用剂量的影响。方法应用PCR—RFLP法检测129例长期口服华法林的患者和198例健康对照者VKORC1-1639G／A多态性，比较VKORC1不同基因型间平均华法林剂量。结果病例组VKORC1-1639AA、AG、GG基因型频率分别为74．4％（96／129）、23．3％（30／129）、2．3％（3／129），等位基因A和G频率分别为86％和14％。病例组与健康对照者VKORC1-1639G／A多态性分布差异无统计学意义（P〉0．05）。VKORC1-1639不同基因型患者所需华法林平均剂量差异有显著统计学意义（P〈0．（301），AA型剂量[（1．444±0．282）mg／INR]显著低于AG型[（1．629±0．258）mg／INR，P=0．002]和GG型患者[（2．031±0．087）mg／INR，P=0．017]。结论中国人华法林应用剂量偏低可能与VKORC1-1639AA型占多数有关。
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| 关 键 词： | 华法林 剂量效应关系,药物 多态性,限制性片段长度 维生素K环氧化物 还原酶复合物1基因 |
Relationship between VKORC1-1639G/A polymorphisms and warfarin dosage in Chinese |
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| WU Xiao-ying,ZHANG Wei-ping,CHEN Hui,LUO Jie-wei. Relationship between VKORC1-1639G/A polymorphisms and warfarin dosage in Chinese[J]. Chinese Journal of Clinicians(Electronic Version), 2008, 2(3): 13-15 |
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| Authors: | WU Xiao-ying ZHANG Wei-ping CHEN Hui LUO Jie-wei |
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| Affiliation: | WU Xiao- ying , ZHANG Wei-ping, CHEN Hui, LU0 Jie-wei, (Fufian Institute of Cardiovascular Disease Research, Fujian Provincial Hospital, Fuzhou 350001, China) |
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| Abstract: | Objective To investigate the relationship between VKORCl-1639 G/A polymorphism and warfarin dosage in Chinese. Methods VKORCl-1639 G/A polymorphism was detected by PCR-RFLP technology in 129 warfarin-treated patients and 198 normal controls. The mean warfarin dosage was compared according to different VKORC1 genotypes. Results The frequencies of the VKORCl-1639 AA, AG, GG genotypes in the patient group were 74.4% （96/129） ,23.3% （30/129）and 2. 3% （3/129）, respectively; allele frequencies were 86% for VKORCl-1639 A and 14% for G. It showed no significant difference in genotype distribution of VKORCl-1639 between the patients and the normal controls. The mean warfarin dosage was significantly different among the VKORC1 genotypes （ P 〈 0. 001 ）. It was much lower in AA genotype （ 1. 444±0. 282 mg/INR） than in AG genotype （ 1. 629± 0. 258 mg/INR） （ P = 0.02） and GG genotype （2. 031 ± 0. 087 mg/INR,P = 0. 017 ）. Conclusions The high frequency of VKORCl-1639 AA genotype might be a cause of lower warfarin dosage in Chinese. |
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| Keywords: | Warfarin Dose-response relationship, drug Polymorphism, restriction fragment length Vitamin K epoxide reductase complex subunit 1 |
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