| 分泌性中耳炎中耳积液血小板活化因子的测定 |
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| 引用本文： | 陈亮,黄以乐,尤景敏,汪建,陈勇挺. 分泌性中耳炎中耳积液血小板活化因子的测定[J]. 临床耳鼻咽喉头颈外科杂志, 2003, 17(10): 607-608 |
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| 作者姓名： | 陈亮 黄以乐 尤景敏 汪建 陈勇挺 |
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| 作者单位： | 广州军区广州总医院耳鼻咽喉科,广州,510010;第一军医大学珠江医院耳鼻咽喉科 |
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| 摘 要： | 目的 :探讨血小板活化因子 (PAF)在分泌性中耳炎 (SOM)发生和转归中的作用。方法 :采用高效液相色谱法测定了 5 6例 (6 8耳 )SOM患者血浆和中耳积液 (MEE)中PAF的含量 ,并以 4 0例正常人血浆作为对照。结果 :SOM患者MEE中PAF浓度明显高于其血浆中的浓度 (P <0 .0 1) ,SOM患者血浆中PAF浓度明显高于对照组血浆中的浓度 (P <0 .0 5 ) ;黏液性中耳积液中的PAF浓度明显高于浆液性中耳积液中的浓度 (P <0 .0 1)。结论 :PAF是SOM中耳积液中的重要炎性递质 ,它与疾病的持续状态相关 ,可能在SOM的病因和发病机制中起着重要的作用
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| 关 键 词： | 中耳炎 分泌性 中耳积液 血小板活化因子 |
| 文章编号： | 1001-1781(2003)10-0607-02 |
| 修稿时间： | 2003-04-03 |
Determination of platelet activating factor in middle ear effusion of patients with secretory oitits media |
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| CHEN Liang HUANG Yile YOU Jingmin WANG Jian CHEN Yongting. Determination of platelet activating factor in middle ear effusion of patients with secretory oitits media[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2003, 17(10): 607-608 |
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| Authors: | CHEN Liang HUANG Yile YOU Jingmin WANG Jian CHEN Yongting |
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| Affiliation: | Department of Otorhinolaryngology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010. |
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| Abstract: | OBJECTIVE: To study the role of platelet activating factor (PAF) in the pathogenesis of secretory otitis media (SOM). METHOD: The content of PAF in blood plasma and middle ear effusion(MEE) were measured in 56(68years) patients with secretory otitis media and in 40 normal subjects respectively by RP-HPLC. RESULT: The concentration of PAF in MEE was remarkably higher than those in blood plasma (P < 0.01). The concentration of PAF in blood plasma in the SOM group was higher than those in the normal control group(P < 0.05). The concentration of PAF of MEE in the mucous fluid group was higher than those in the serous fluid group(P < 0.01). CONCLUSION: PAF might be an important mediator in MEE of SOM, it might be closely related to the persistence of SOM, and might play an important role in the pathogenesis of SOM. |
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| Keywords: | Secretory otitis media Middle ear effusion Platelet activating factor |
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