| 硫氮酮和异搏定治疗高血压时的血脂变化 |
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| 引用本文： | 王宪衍,邱慧丽,范明昌,龚兰生,孙铭华,熊吉林. 硫氮酮和异搏定治疗高血压时的血脂变化[J]. 上海交通大学学报(医学版), 1991, 0(1) |
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| 作者姓名： | 王宪衍 邱慧丽 范明昌 龚兰生 孙铭华 熊吉林 |
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| 作者单位： | 上海第二医科大学上海市高血压研究所(王宪衍，邱慧丽，范明昌，龚兰生)，上海新力机器厂医务室(孙铭华)，上海无线电四厂医务室(熊吉林) |
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| 摘 要： | 53例原发性高血压患者,随机分为两组,分别用硫氮酮(diltiazem)和异搏定(verapamil)治疗,疗程4周。用双盲法观察降压效果和血脂改变。结果两组均示有明显降压效果,硫氮(艹卓)酮的降压效果又明显大于异搏定。治疗后的血脂改变,两组均显示有:HDL-C,HDL-C/TC比值,HDL_C/LDL-C比值和ApoAl的升高,且两组间比较无显著差异。这些改变均有利于防止动脉粥样硬化,故认为,两者对血脂代谢的影响虽相似,但硫氮(艹卓)酮对心脏抑制作用较异搏定为轻,降压疗效较异搏定为佳,故在治疗高血压时,硫氮(艹卓)酮更值得推广应用。
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| 关 键 词： | 硫氮酮 异搏定 脂蛋白类 高密度脂蛋白-胆固醇 原发性高血压 |
The Effects on Serum Lipids of Diltiazem and Verapamil in Patients with Essential Hypertension |
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| Wang Xianyan,et al Shanghai Institue of Hypertension,Shanghai Second Medical University,Shanghai. The Effects on Serum Lipids of Diltiazem and Verapamil in Patients with Essential Hypertension[J]. Journal of Shanghai Jiaotong University:Medical Science, 1991, 0(1) |
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| Authors: | Wang Xianyan et al Shanghai Institue of Hypertension Shanghai Second Medical University Shanghai |
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| Abstract: | In a randomized, double blind trial, diltiazem and verapamil were compared in 53 patients with essential hypertension. Both diltiazem and verapamil had significant effects on blood pressure, and the blood pressure was lowered more in patients taking diltiazem than in those taking verapamil. The changes in serum lipids were (1) an increase of HDL-C, HDL-C/TC ratio and HDL-C/LDL-C radio; (2) an increase of ApoAl. These changes are favorable to atherosclerosis prevention. The authors suggestth at diltiazem will be used widely in hypertensive, especially in patients associated with angina pectoris, hyperlipidemia and increased heart rate. |
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| Keywords: | diltiazem verapamil lipoproteins HDL-C essential hypertension |
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