辛伐他汀对急性冠脉综合征患者hs-CRP影响的观察

目的：探讨辛伐他汀对血脂正常的急性冠脉综合征（ACS）患者冠脉病变炎症的影响。方法：将98例ACS患者随机分为辛伐他汀治疗组（观察组）49例和常规治疗组（对照组）49例，另设健康组49例．测定治疗前、治疗后8周血清超C反应蛋白（hs—CRP）的变化。结果：98例ACS患者的hs—CRP水平均显著高于健康组；对照组治疗8周后，hs—CRP与治疗前相比差异有统计学意义（P〈0．05），而观察组经辛伐他汀8周治疗后，hs—CRP与治疗前相比差异有统计学意义（P〈0．01）。结论：辛伐他汀对ACS患者的炎症反应有明显的抑制作用。

The observation of the effect of simvastatin on acute coronary syndrome patients with hs-CRP

Objective：To investigate the effect of simvastatin on blood lipids of normal acute coronary syndrome （ACS） in patients with coronary artery inflammation. Methods ：98 cases of ACS patients were randomly divided into simvastatin treatment group （observation group）, 49 cases of conventional therapy group （control group） and a separate group of 49 cases of health. To measure changes of hs-CRP before treatment, 8 weeks after treatment. Results：98 cases of ACS patients with hs-CRP were significantly higher than the healthy group; 8 weeks after treatment, hs-CRP of the control group compared with the pre-treatment differences were significant （P〈0.05）, while hs-CRP of observation group compared with the pre-treatment differences were significant （P〈0.01）. Conclusion ：The simvastatin on the inflammatory response of ACS patients has significantly restraining effect.