卵源性因子在多囊卵巢综合征卵泡异常发育机制中的作用

多囊卵巢综合征(PCOS)是育龄期女性最常见的生殖内分泌紊乱疾病,可表现为高雄激素血症,高胰岛素血症,胰岛素抵抗,并可引起生殖功能的障碍,该病与卵泡发育异常密切相关。卵泡发育是一个极为复杂的过程,而PCOS患者在此过程中出现募集亢进和无优势卵泡形成。现主要介绍卵源性因子如何调控生理情况下的卵泡发育及其在PCOS患者卵泡异常发育的病理机制中所起的作用。卵源性因子主要包括内分泌因子、生长因子、细胞因子等,它们可单因素或多因素地参与卵泡发育的调控。

Function of Ovarian Factors in the Abnormal Development of Ovarian Follicle in Polycystic Ovarian Syndrome

Polycystic ovarian syndrome(PCOS) is the most common reproductive endocrine disorder syndrome of reproductive women characterized by ovarian hyperandrogenism,hyperinsulinemia,insulin resistance,and reduced fecundity,and the disease is closely related to abnormal ovarian follicle development.The development of ovarian follicle is very complex.And women with PCOS have the characteristic of follicle rising concentration and have no matured follicles in the progress.Here is to elaborate on ovarian factors roles in follicular development in physiological state and in the pathogenesis of PCOS.Ovarian factors mainly include endocrine factors,growth factors and cytokines etc.,and follicular development and regulation are modulated by one factor or more.