银杏叶提取物对阿尔茨海默病记忆功能影响的研究

目的观察银杏叶提取物对阿尔茨海默病(AD)患者记忆功能和局部脑血流量的影响,探讨其对AD的临床疗效。方法选取2009年10月至2011年10月在解放军白求恩国际和平医院神经内科就诊并被确诊为AD的患者220例,用随机抽取号码法分为对照组110例和治疗组110例。对照组患者给予安慰剂治疗,治疗组给予银杏叶提取物治疗,疗程均为6个月。比较治疗前后所有患者的简易精神状况量表(MMSE)评分、单光子发射计算机断层扫描核素显像检测各个脑区放射性比值(RAR)。结果与治疗前相比,治疗组MMSE评分及RAR的各项指标显著升高(P<0.05),对照组MMSE评分及RAR的各项指标与治疗前相比无统计学意义(P>0.05)。结论银杏叶提取物具有提高AD患者记忆力并改善局部脑组织血流量的功效。

The Effect of Extract of Ginkgo Biloba Leaf on Memory Function of Alzheimer Disease

Objective To investigate the clinical efficacy of extract of ginkgo biloba leaf(EGb) on Alzheimer disease(AD) by observing the impact on memory function and regional cerebral blood flow.Methods Two hundred and twenty elderly patients diagnosed to AD from the people's Liberation Army Heping Hospital Bethune International during Oct.2009 and Oct.2011 were randomly divided into control group and treatment group,each group with 110 cases.The patients in control group were treated by placebo;the patients in treatment group were treated by EGb.The course of the therapy lasted 6 months.MMSE score and RAR of all patients were recorded and compared before and after treatment.Results Compared with before treatment,the MMSE score and RAR of the treatment group increased significantly(P < 0.05),but there was no statistically difference in control group(P > 0.05).Conclusion EGb can improve memory function and local cerebral blood flow of patients with Alzheimer disease.