慢性肾功能不全合并胃食管反流病患者血清尿素氮、血肌酐及食管24hpH值DeMeester评分与胃泌素的相关性

目的探讨慢性肾功能不全合并胃食管反流病患者血清尿素氮、肌酐及食管24 h pH值DeMeester评分与胃泌素的相关性。方法选取南京军区南京总医院门诊慢性肾功能不全合并胃食管反流病的患者42例,测定血清尿素氮、肌酐及胃泌素浓度,并行24 h食管pH监测,结果以DeMeester评分进行统计。观察患者肾功能及DeMeester评分与血清胃泌素的关系。结果血清尿素氮为(31.1±8.5)mg/dl,肌酐为(3.0±1.3)mg/dl,DeMeester评分为65.0±64.1,胃泌素为(63.5±18.7)pg/ml;血清尿素氮、肌酐和DeMeester评分与胃泌素均呈正相关,相关系数R2值分别为0.58、0.49、0.35。结论慢性肾功能不全患者出现胃食管反流症状可能是由于对胃泌素的清除减少和生成增多导致的胃酸分泌增加及反流增多所致。

The correlation of serum urea nitrogen,creatinine and DeMeester score with gas- trin in chronic renal insufficiency with gastroesophageal reflux disease

Objective To investigate the correlation of serum urea nitrogen, serum creatinine and 24 hours esophageal pH value DeMeester score with gastrin in chronic renal insufficiency with gastroesophageal reflux disease （GERD）. Meth- ods Forty-two patients who had chronic renal insufficiency with GERD were involved in this study. The serum urea nitro- gen, creatinine, gastrin concentration and 24 hours esophageal pH results DeMeester score were analyzed. The correlation of serum gastrin with renal function and DeMeester score were analyzed. Results The results of serum urea nitrogen, ser- um ereatinine, DeMeester score and gastrin were （31.1 ±8. 5 ） mg/dl, （3.0 ± 1.3 ） mg/dl, （65.0 ± 64.1 ） and （63.5 ± 18. 7 ） pg/ml, respectively. The urea nitrogen, ereatinine and DeMeester score were positively correlated with the gastrin con- centration. The correlation coefficient R2 values were 0.58, 0.49 and 0.35, respectively. Conclusion Patients who had chronic renal insufficiency presented with gastroesophageal reflux symptoms may be due to the reduced clearance and increased production of gastrin, which induced gastric acid secretion and reflux increasing.