| Htert、CD133和c-myc在胃癌中的表达 |
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| 引用本文： | 林照亮,;黄雪连,;戴少敏,;吴盛州,;龚梅金,;张永顶,;吴炎,;周其才. Htert、CD133和c-myc在胃癌中的表达[J]. 胃肠病学和肝病学杂志, 2014, 0(7): 749-751 |
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| 作者姓名： | 林照亮, 黄雪连, 戴少敏, 吴盛州, 龚梅金, 张永顶, 吴炎, 周其才 |
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| 作者单位： | [1]深圳市西丽人民医院消化内科,广东深圳518055; [2]深圳市南山区人民医院消化内科,广东深圳518055; |
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| 基金项目： | 深圳市科技计划项目（201103327） |
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| 摘 要： | 目的探讨肿瘤干细胞及其Wnt信号通路表达在胃癌患者中的作用机制。方法利用免疫组化技术分析c-myc基因蛋白、hTERT及CD133在慢性非萎缩性胃炎、慢性萎缩性胃炎(伴肠化生或异型增生)、早期胃癌患者非炎症区组织中的表达,并对其进行比较。结果在早期胃癌组与慢性萎缩性胃炎组,c-myc基因蛋白、hTERT及CD133的表达均明显高于慢性非萎缩性胃炎组(P0.05);但早期胃癌组与慢性萎缩性胃炎组相比,c-myc基因蛋白、hTERT及CD133的表达差异无统计学意义(P0.05)。结论胃癌和胃癌前病变与c-myc基因蛋白、hTERT及CD133的过表达密切相关,在胃癌发病中具有重要意义。
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| 关 键 词： | 肿瘤干细胞 Wnt信号通路 胃癌 癌前病变 c-myc基因蛋白 hTERT CD133 |
Expression of Htert,CD133 and c-myc in gastric cancer |
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| Affiliation: | LIN Zhaoliang,HUANG Xuelian,DAI Shaomin,WU Shengzhou,GONG Meijin,ZHANG Yongding,WU Yan( 1.Department of Gastroenterology, Xili People＇s Hospitle of Shenzhen, Shenzhen 518055; 2.Department of Gastroenterology, Nanshan District, Xili People＇s Hospital, Shenzhen City, China;) |
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| Abstract: | Objective To investigate the mechanism and expression of cancer stem cells and Wnt signaling pathway in patients with gastric cancer.Methods hTERT gene,CD133 protein and c-myc gene protein were analyzed by immunohistochemistry method.Results Expression of hTERT gene,CD133 protein and c-myc gene protein were significantly higher in early-stage gastric cancer and chronic atrophic gastritis than those in chronic non-atrophic gastritis （P ＜ 0.05）.There were no significant differences of expression of hTERT gene,CD133 protein and c-myc gene protein between early-stage gastric cancer group and chronic atrophic gastritis group （P ＞ 0.05）.Conclusion Over-expression of hTERT gene,CD133 protein and c-myc gene protein have close relation to gastric cancer and precancerous lesion of gastric cancer and they have great significance in the carcinogenesis of gastric cancer. |
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| Keywords: | Tumor stem cell Wnt signaling pathway Gastric cancer Precancerous lesion c-Myc gene protein hTERT CD133 |
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