肠道菌群失调与功能性腹泻

功能性腹泻(functional diarrhea,FD)主要表现为排便频次的增多及粪便性状的改变,且至少75%不伴有腹痛。它是临床上常见的一种功能性肠病,其发病率仅位居肠易激综合征之后,我国的发病率显著低于西方国家,但在亚洲相对较高。FD的病因和发病机制复杂,而肠道菌群失调被认为是其主要致病因素之一,因此,调节肠道菌群失调、恢复肠道微生态平衡是治疗FD的有效途径,且国内外多项研究表明,应用微生态制剂可有效调节肠道菌群失调,并能明显缓解FD的症状。本文着重就FD和肠道菌群失调的关系及应用微生态制剂治疗FD的疗效作一概述。

Alteration of intestinal flora and functional diarrhea

Functional diarrhea （FD） is defined as the increased frequency of defecation and stool changes and at least 75％ without abdominal pain.It is a common functional bowel disease.Its prevalence is just behind the irritable bowel syndrome.The prevalence of functional diarrhea in China is substantially lower than that in Western countries and relatively higher than that in other Asian countries.The etiology and pathogenesis of functional diarrhea are complex and the alteration of intestinal flora is considered to be one of the main pathogenic factors.Therefore,regulating the intestinal dysbacteriosis and restoring the gut microflora balance are effective ways to treat functional diarrhea and a number of previous studies have shown probiotics efficacy in regulating the intestinal dysbacteriosis and which can obviously relieve the symptoms of functional diarrhea.This review focused on the relationship between functional diarrhea and alteration of intestinal flora,and the effect of probiotics in treatment of the functional diarrhea.