幽门螺杆菌感染与儿童支气管哮喘发病的相关性研究

目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染与儿童支气管哮喘发病的关系。方法采用14C呼气试验检测H.pylori感染,比较H.pylori感染儿童与正常儿童之间的哮喘发病率和病情发展情况。结果 H.pylori感染儿童哮喘发病率较正常儿童低(6.33%vs 12.66%,P0.05);H.pylori阳性的哮喘儿童较H.pylori阴性的哮喘儿童拥有更长的缓解期(P0.05)。结论H.pylori感染与儿童哮喘的发病和复发呈负相关,具体机制有待进一步研究。

Association between Helicobacter pylori infection and bronchial asthma in children

Objective To investigate the association between Helicobacter pylori （H.pylori） infection and bronchial asthma in children.Methods The infection of H.pylori was detected with 14C urea breath testing.The incidence and progression of asthma in H.pylori-positive and H.pylori-negative children were compared.Results The incidence of asthma in H.pylori-positive children was lower than that in H.pylori-negative children （6.33％ vs 12.66％,P ＜ 0.05）.Asthma children with H.pylori infection had a longer remission than those without H.pylori infection （P ＜ 0.05）.Conclusion There is a negative correlation between H.pylori infection and the incidence and recurrence of bronchial asthma,however,the mechanisms need further research.