门冬氨酸鸟氨酸联合纳洛酮治疗急性肝性脑病的临床疗效观察

目的观察门冬氨酸鸟氨酸联合纳洛酮治疗急性肝性脑病的临床疗效。方法选取北京市第六医院2010年-2012年诊治的60例急性肝性脑病患者,随机分为门冬氨酸鸟氨酸治疗组(对照A组)15例、纳洛酮治疗组(对照B组)15例和门冬氨酸鸟氨酸联合纳洛酮治疗组(实验组)30例。各组均治疗7 d,对其治疗前后血氨浓度、肝功能(AST、TBIL)水平进行评价和比较,同时比较各组患者的临床疗效。结果治疗后对照A组和对照B组患者与实验组患者相比,其血氨及AST、TBIL水平差异均有统计学意义(P0.05),且实验组显效率及总有效率(63.33%,90.00%)明显高于对照组(33.33%,63.33%),差异具有统计学意义(P0.05)。结论门冬氨酸鸟氨酸联合纳洛酮治疗急性肝性脑病可以有效改善患者临床症状,提高临床疗效。

The clinical effect of Ornithine Aspartate combined with naloxone in treatment of acute hepatic encephalopathy

Objective To observe the clinical effect of Ornithine Aspartate combined with naloxone in treatment of acute hepatic encephalopathy.Methods Sixty cases of acute hepatic encephalopathy were selected in the Sixth Hospital of Beijing from 2010 to 2012,and randomly divided into Ornithine Aspartate treatment group （control group A,15 cases）,Naloxone treatment group （control group B,15 cases） and Ornithine Aspartate combined naloxone treatment group （experimental group）with 30 cases.The changes of concentrations of plasma ammonium and total bilirubin （AST）,aspartate transamlnase （TBIL） after 7 days treatment were compared,and the clinical effect in each group was compared.Results After 7 days treatment,the concentrations of plasma ammonium,AST,TBIL of experimental group were significant difference compared with control group A and control group B （P ＜ 0.05）,and the efficiency and total effective rate of experimental group （63.33％,90.00％） was significantly higher than those of control group （33.33％,63.33％） （P ＜ 0.05）.Conclusion Ornithine Aspartate combined with naloxone in treatment of acute hepatic encephalopathy can effectively ameliorate the clinical symptoms,and improve the clinical curative effect.