西咪替丁治疗轮状病毒肠炎患儿疗效观察

目的观察使用西咪替丁治疗轮状病毒肠炎患儿的疗效及对血清细胞因子的影响。方法将98例轮状病毒肠炎患者随机数字表法分为对照组和观察组。对照组应用抗病毒药物(利巴韦林)10 mg/(kg·d)静脉滴注治疗,在此基础上,观察组患者给予10 mg/(kg·d)的西咪替丁静脉滴注治疗;比较两组治疗有效率、平均止泻时间、平均止吐时间和治疗前后血清IL-2、IFN-γ、TNF-α水平的差异。结果观察组治疗总有效率达91.8%,高于对照组的40.8%(P0.05)。观察组患者治疗后平均退热时间和平均止泻、止呕时间均较对照组患者显著缩短(P0.05),不良反应发生率较对照组明显减少(P0.05)。治疗后观察组患者血清中IL-2、IFN-γ水平较对照组显著升高,TNF-α的含量水平与对照组比较显著降低(P0.05)。结论西咪替丁治疗轮状病毒肠炎患儿可短时间内止泻、止呕,改善血清细胞因子水平,疗效明显,且无明显副作用产生,值得临床推广使用。

Efficacy observation of cimetidine in the treatment of children with rotavirus enteritis

Objective To observe the efficacy and effect on serum cytokine of cimetidine in children with rotavirus enteritis.Methods Ninety-eight cases of rotavirus gastroenteritis were randomly divided into control group and observation group.The control group were treated with antiviral drugs （ribavirin） 10 mg/（kg · d） intravenous infusion therapy,on the basis of the control group,the observation group were treated with 10 mg/（kg · d） intravenous infusion of cimetidine; the average antidiarrheal time,average antanacathartic time,and serum levels of antiemetic IL-2,IFN-γ,TNF-α were detected and compared between two groups.Results The total efficiency of observation group was 91.8％,higher than the control group （40.8％,P ＜ 0.05）.Mean fever clearance time,the average antidiarrheal time,antanacathartic time of the observation group after treatment were significantly reduced than those of the control group （P ＜ 0.05）,the incidence of adverse reactions was significantly reduced in the observation group compared with the control group （P ＜ 0.05）.After treatment,serum IL-2,IFN-γ levels were significantly higher in observation group than those in the control group,TNF-α content level was significantly lower than that in the control group （P ＜ 0.05）.Conclusion In the treatment of rotavirus enteritis,cimetidine can restrain diarrhea,vomiting,improve serum cytokine levels in short period,and it has no significant side effect,is worthy of clinical use.