1例初诊酒精性肝病患者的循证治疗

目的借助循证医学的方法为1例初诊酒精性肝病患者确定治疗方案。方法根据患者情况提出临床问题,在Cochrane图书馆、PubMed、Embase、维普资讯上检索,并对相关证据进行评价,结合医生经验及患者意愿制定治疗方案。结果共纳入相关文献16篇,分析后对该患者确定治疗方案:水飞蓟宾(利加隆胶囊140 mg,tid)降转氨酶+泼尼松龙(40 mg/d,28 d)非特异性抗炎治疗。经10个月的随访,证实该方案对患者安全有效。结论采用循证治疗的方法,为初诊酒精性肝病患者确定合理的治疗方案,可有效提高治疗效果。

Evidence-based treatment for a patient with alcoholic liver disease

Objective To formulate an evidence-based treatment plan for a patient with alcoholic liver disease. Methods According to the clinical problems, evidence were collected from the Cochrane Library, PubMed, Embase, VIP Information. The patient preference and physician clinical experience were also taken into consideration in the decision-making treatment. Results Totally 16 literatures were identi- fied. According to the patient＇ s condition, antioxidant supplements and glucocorticoid were introduced, and the therapy was approved to be safe and effective in the patient after 10 months follow-up. Conclusion The treatment efficacy in diagnosed alcoholic liver disease has been improved by determining an individualized treatment plan according to evidence-based methods.