Methylation analysis of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma |
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| Authors: | Yang Yang Takeuchi Seisho Tsukasaki Kunihiro Yamada Yasuaki Hata Tomoko Mori Naoki Fukushima Atsuki Seo Hiromi Koeffler H Phillip Taguchi Hirokuni |
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| Affiliation: | Department of Medicine, Kochi Medical School, Okohcho, Nankoku, Kochi 783-8505, Japan. |
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| Abstract: | We investigated methylation status of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma (ATL). APC methylation was found in 15 of 31 (48%) primary samples, and 2 of 4 (50%) ATL cell lines. Methylation of the APC gene occurred more frequently in acute ATL (12/21) (57%) than chronic ATL (1/8) (13%) (P = 0.03). APC was not expressed in the APC-methylated ATL cell line ST1. Demethylation with 5-azacytidine treatment restored APC expression in the ST1 cell line. Our data show that hypermethylation of the APC gene is involved in the pathogenesis of ATL. |
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