Expression of FAK-related non-kinase (FRNK) coincides with morphological change in the early stage of cell adhesion |
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Authors: | Yuuki Nagoshi Gou Yamamoto Tarou Irie Tetsuhiko Tachikawa |
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Institution: | (1) Department of Oral Pathology and Diagnosis, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan |
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Abstract: | Focal adhesion kinase (FAK), a protein tyrosine kinase, has recently been suggested to play a role in signal transduction
through integrins. In fact, FAK is involved in cell proliferation and cell motility by performing signal transduction through
integrins. FAK-related non-kinase (FRNK) has been found to be an inhibitor of FAK. As the expression level of FRNK in the
cell is very low, the study of FRNK has been preferentially performed by gene overexpression, up to the present, and the role
of constitutive FRNK in cells remains unclear. We hypothesized that FRNK is involved in the adhesion of cells to the extracellular
matrix (ECM) and investigated the expression of FRNK by time kinetic analysis shortly after cell seeding. We found that FRNK
expression was significantly increased in the cells during the early stage of cell adhesion to the ECM. These data indicated
that FRNK plays an important role in cell adhesion during the very early stages of cell culture. |
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Keywords: | Focal adhesion kinase FAK-related non-kinase Early stage of cell adhesion Squamous cell carcinoma |
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