淋球菌对氟喹诺酮类药物的耐药性研究

为了解淋球菌对氟喹诺酮类药的耐药性，用琼脂稀释法和纸片扩散法分别对１９８～１９９９年间广东省湛江地区分离出的９８株洒球菌流行株进行了药物敏感性测定。测定了流行株对诺氟沙星、依诺沙星、环丙沙星、氧氟沙星和洛美沙星５种氟喹诺酮类药物的最小抑菌浓度（ＭＩＣ）和抑菌圈直径（ｍｍ），根据ＮＣＣＬＳ标准判定敏感与耐药。结果表明，纸片扩散法测定淋球菌对这５种抗生纱的耐药百分率分别为９１．８４％、９７．９６％、８

Study on the resistance of Neisseria gonorrhoeae to fluoroquinolone

In order to measure the resistance of Neisseria gonorrhoeae to fluoroquinolone, 98 gonococcal epidemic strains obtained from 1998 through 1999 in Zhanjiang (Guangdong) were tested for their antibiotic susceptibilities by using disk diffusion and agar dilution methods. The minimum inhibitory concentrations (MICs) and inhibition zone diameters(mm) were detected to norfloxacin, enoxacin, ciprofloxacin, ofloxacin and lomefloxacin. Then defined the susceptible and resistant strains based on the criteria of NCCLS. The results indicated that the resistant percentages of Neisseria gonorrhoeae to this five antibiotics were 91.84%, 97.96% , 84.70%, 75.51% and 87.76% respectively by using disk diffusion method. At the same time, the resistant percentages by using agar dilution method were 83.50%, 91.20%, 59.30%, 53.80% and 75.80%, respectively. Results showed that the resistant strains of Neisseria gonorrhoeae to fluoroquinolone in Zhanjiang were serious, the clinical physicians must pay more attention to the resistance in treatment for gonorrhea in this area.