T Cell Receptor Expression And Activation Of Synovial Lymphocyte Subsets In Patients With Rheumatoid Arthritis |
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Authors: | Thierry Ré me,Marielle Portier,Florence Frayssinoux,Bernard Combe,Pierre Miossec,Franç ois Favier,Jacques Sany |
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Abstract: | Two-color flow cytometry analysis of peripheral blood and synovial lymphocytes from rheumatoid arthritis patients was performed using monoclonal antibodies directed against T cell subsets, T cell activation markers, and T cell receptors. The results showed an abnormally high percentage (>15%) of CD3+, CD4−, and CD8− T cells expressing a specific receptor containing a γ chain. Phenotypic analysis of lymphocytes infiltrating both knee joints of individual rheumatoid arthritis patients revealed very similar subset distribution and activation levels, despite strong differences in the clinical status between the 2 sites. |
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