脑微出血与脑小血管病患者认知功能障碍的相关性研究

目的 探讨脑微出血（cerebral microbleeds，CMBs）与脑小血管病患者认知功能障碍的相关性。方法 选取2020年1月至2022年12月南京中医药大学连云港附属医院脑病科收治的脑小血管病患者80例为研究对象，依据大脑半球有无CMBs分为CMBs阳性组（50例）和CMBs阴性组（30例）。比较两组患者的一般临床资料，采用蒙特利尔认知评估量表（Montreal cognitive assessment scale，MoCA）评估患者的认知功能。结果 CMBs阳性组患者的年龄、高血压发生率均显著高于CMBs阴性组（P<0.05）。CMBs阳性组患者的MoCA总分及视空间与执行功能、抽象思维、延迟回忆评分均显著低于CMBs阴性组（P<0.05）。结论 CMBs与脑小血管病患者认知损害的潜在机制、临床诊断及程度评估密切相关。

Correlation study between cerebral microbleeds and cognitive dysfunction in patients with cerebral small vessel disease

Objective To explore correlation between cerebral microbleeds (CMBs) and cognitive dysfunction in patients with cerebral small vessel disease. Methods A total of 80 patients with cerebral small vessel disease admitted to Department of Encephalopathy in Nanjing University of Chinese Medicine Affiliated Lianyungang Hospital from January 2020 to December 2022 were selected as research objects. They were divided into CMBs positive group (50 cases) and CMBs negative group (30 cases) based on the presence or absence of CMBs in the cerebral hemisphere. General clinical data of two groups were compared. Cognitive function was assessed by using Montreal cognitive assessment scale (MoCA). Results Age and incidence rate of hypertension in CMBs positive group were significantly higher than those in CMBs negative group (P<0.05). Total score of MoCA, scores of visuospatial and executive function, abstract thinking and delayed recall in CMBs positive group were significantly lower than those in CMBs negative group (P<0.05). Conclusion CMBs are closely related to the potential mechanism, clinical diagnosis and degree assessment of cognitive dysfunction in patients with cerebral small vessel disease.