妊娠相关血浆蛋白A正常参考值的研究

目的:确定不同孕周的孕妇其妊娠相关血浆蛋白A(PAPP-A)的正常参考值,分析PAPP-A水平与不良妊娠的关系。方法:用酶联免疫吸附试验(ELISA)测定孕妇血清PAPP-A浓度,并分组讨论不良妊娠与PAPP-A的关系。结果:获得4~42周PAPP-A浓度中位数、0.5倍中位数、2.5倍中位数。PAPP-A低值与胎儿核型异常、难免流产、死胎有关;PAPP—A高值与双胎、中重度妊高征有关;先兆流产预后差者PAPP-A值低于先兆流产预后佳者。结论:从2 800例孕妇血清中得到的PAPP-A浓度统计值0.5~2.5 MoM可作为正常参考,试用于我省产前筛查;母体血清PAPP-A的测定值可作为胎儿染色体异常、流产、死胎、妊高征及双胎的辅助诊断指标。

The studyp on our laboratory''''s expected of pregnancy - associated plasma protein A

Objective:To establish our laboratory's expected PAPP-A concentration values and to analyze the relationship between the serum level of PAPP-A and disadvantage pregnancies.Methods:Blood samples from 2 800 pregnant women were assayed for PAPP-A by enzyine linked immnnosorbent assay-ElliSA-Kits.SPSS 80 software was performed to obtain the expected PAPP-A values.All of the disadvantage pregnancies in grouped were analyzed about PAPP-A concentration.Results:Tile expected values of 4~42 week of maternal serum PAPP-A were obtained,including median 0.5 multiple of median,and 2.5 multiple of median.The lower levels of PAPP-A were involved in fetal chromosomal anomalty,inevitable abortion,and fetal death.The higher levels were involved in pregnancy-induced hypertension and twins.In threatened abortion,women with high level of PAPP-A would have be er prognosis than those with lower levels.Conclusion:The expected PAPP-A concentration values from 2 800 maternal serum are useful in our labortory at present.PAPP-A as maternal serum marker is helpful in prenatal screening.