| 血浆蛋白质在生物材料表面吸附时的Vroman效应 |
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| 引用本文： | 黄嘉.血浆蛋白质在生物材料表面吸附时的Vroman效应[J].生物医学工程学杂志,1999,0(3):371-376. |
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| 作者姓名： | 黄嘉 |
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| 作者单位： | 四川大学西区高分子材料系生物及生物技术研究所!成都610065(黄嘉，乐以伦)，四川大学生物医学工程研究所!成都610065(郑昌琼) |
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| 摘 要： | 以吸附时间，血浆稀释倍数，狭窄空间的高度为变量研究纤维蛋白原（Ｆｇ）从血浆吸附到生物材料表面时，会发现Ｆｇ的吸附出现一最大值，此即Ｖｒｏｍａｎ效应，研究证实Ｖｒｏｍａｎ效应并非纤维蛋白原所独有的现象，而是一普遍现象，它反映了血浆中的蛋白质对表面有限位点的竞争吸附。我们综述了影响血浆蛋白南在生物材料表面吸附时的Ｖｒｏｍａｎ疚的实验因素，Ｖｒｏｍａｎ效应的机理以及Ｖｒｏｍａｎ效应对于研究血液－材料相互
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| 关 键 词： | 血浆蛋白 吸附 Vroman效应 生物材料 |
Vroman Effect of Plasma Protein Adsorption to Biomaterials Surfaces |
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| Huang Jia,Yue Yilun,Zheng Changqiong.Vroman Effect of Plasma Protein Adsorption to Biomaterials Surfaces[J].Journal of Biomedical Engineering,1999,0(3):371-376. |
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| Authors: | Huang Jia Yue Yilun Zheng Changqiong |
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| Institution: | Biomaterials and Biotechnology Institute, Department of Polymer Materials and Sciences, Sichuan University, Chengdu 610065. |
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| Abstract: | Fibrinogen adsorption from plasma to biomaterials surfaces passes through a maximum when studied as a function of adsorption time, plasma concerntration, or column height in narrow spaces and these are called Vroman effect. Studies have demonstrated that Vroman effect is a general phenomenon of plasma proteins and reflects the competitive adsorption of plasma proteins for a limited number of surface sites. In this paper,the factors affecting Vroman effect, the relationship between contact activation and fibrinogen displacement, and the significance of the Vroman effect with respect to blood material interactions are reviewed. |
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| Keywords: | Plasma protein Adsorption Vroman effect |
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