| DNA损伤修复与肿瘤烷化剂化疗 |
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| 引用本文： | 郑长青,季守平,章扬培. DNA损伤修复与肿瘤烷化剂化疗[J]. 军事医学科学院院刊, 2009, 33(1): 77-80 |
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| 作者姓名： | 郑长青 季守平 章扬培 |
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| 作者单位： | 1. 军事医学科学院野战输血研究所,北京,100850;解放军第401医院,山东青岛,266071
2. 军事医学科学院野战输血研究所,北京,100850 |
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| 摘 要： | DNA损伤修复能够使肿瘤细胞耐受化疗药物造成的DNA损伤而存活，因此，调节某种特殊的DNA修复路径可以增强化疗药物的疗效。另外，有些DNA修复路径在一些肿瘤细胞中是失活的。目前，以DNA修复蛋白O^6甲基鸟嘌呤-DNA甲基转移酶（MGMT）和错配修复蛋白作为调节靶标，提高化疗效果的联合用药策略正在进行各期临床实验。靶向DNA修复机制增强抗肿瘤化疗药物的疗效、克服肿瘤耐药正成为肿瘤个体化化疗研究的一个重要领域。
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| 关 键 词： | DNA修复 烷化剂 肿瘤治疗 药物耐受性 |
DNA repair and alkylating chemotherapeutic agents |
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| ZHENG Chang-Qing,JI Shou-ping,ZHANG Yang-Pei. DNA repair and alkylating chemotherapeutic agents[J]. Bulletin of the Academy of Military Medical Sciences, 2009, 33(1): 77-80 |
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| Authors: | ZHENG Chang-Qing JI Shou-ping ZHANG Yang-Pei |
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| Affiliation: | ZHENG Chang-Qing, JI Shou-Ping, ZHANG Yang-Pei( 1. Department of Biochemistry and Molecular Biology, Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100550, China; 2. Department of Blood Transfusion, No. 401 Hospital of PLA, Qingdao, Shandong, 266071, China) |
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| Abstract: | DNA repair pathways can enable tumor cells to survive DNA damage induced by anti-tumor drugs such as alkylating agents. Therefore, modulating specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, some of these pathways were inactivated in certain cancers. Modulation of O^6-methylguanine-DNA methyhransferase（MGMT） and mismatch repair（MMR） expression in tumors and normal tissue is currently being investigated as a possible strategy for improving cancer therapy. Improving the efficacy of standard chemotherapy and surmounting chemotherapeutic alkylating drug resistance by targeting DNA repair mechanisms is becoming an important area in cancer research. |
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| Keywords: | DNA |
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