Putrescine metabolism in human brain tumors |
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| Authors: | Stephen S Goldman Nora D Volkow Jonathan Brodie Eugene S Flamm MD |
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| Affiliation: | (1) Department of Neurosurgery, New York University Medical Center, 550 First Avenue, 10016 New York, New York, USA;(2) Department of Psychiatry and Behavioral Sciences, University of Texas at Houston, Houston, TX;(3) Department of Psychiatry, New York University Medical Ceneter, New York, NY |
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| Abstract: | Summary The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed. |
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| Keywords: | brain tumors polyamines putrescine positron emission tomography |
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