巨噬细胞移动抑制因子在2型糖尿病合并冠心病中的作用研究

目的探讨巨噬细胞移动抑制因子(MIF)水平与2型糖尿病(T2DM)合并冠心病(CHD)的关系及其临床意义。方法选取T2DM合并CHD(T2DM+CHD组)患者46例、单纯T2DM(T2DM组)患者45例、单纯CHD(CHD组)患者44例、门诊体检者(对照组)45例,检测各组血清MIF水平、空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)浓度、糖化血红蛋白(HbA1c)和空腹血清胰岛素(FINS),计算胰岛素抵抗指数(HOMA-IR)、体重指数(BMI),并作相关分析。结果 T2DM+CHD组血清MIF水平均明显高于T2DM组、CHD组和对照组,差异均有统计学意义(q分别=2.58、2.33、2.87,P均<0.05)。T2DM+CHD组和T2DM组MIF水平均与TG、HbA1c呈正相关(r分别=0.35、0.26、0.29、0.31,P均<0.05);T2DM与MIF、HbA1c密切相关(OR分别=2.11、1.09,P均<0.05),T2DM合并CHD与MIF、TG密切相关(OR分别=3.95、2.29,P均<0.05)。结论血清MIF与T2DM合并CHD的发病有一定联系。

Roles of macrophage migration inhibitory factor in patients with type2 diabetes mellitus combined with coronary heart disease

Objective To evaluate the clinical significance of macrophage migration inhibitory factor（MIF） in patients of type2 diabetes mellitus（T2DM） combined with coronary heart disease（CHD）. Methods Serum samples were taken from 46 patients of T2DM combined with CHD, 45 patients of T2DM, 44 patients of CHD and 45 healthy controls. MIF, fasting blood glucose（FBG）, total cholesterol（TC）, triglyceride（TG）, high density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C） levels, HbA1c and fasting serum insulin（FINS） were detected. HOMA-IR and body mass index （BMI） were calculated. Pearson correlation analysis and multiple linear analysis were used. Results The T2DM combined with CHD group had significantly higher levels of MIF than T2DM group, CHD group and control group（q=2.58, 2.33, 2.87, P〈0.05）. Pearson correlation analysis showed that the MIF level was positively related to TG and HbA1c （r=0.35, 0.26, 0.29, 0.31, P〈0.05）. Multiple linear analysis showed that MIF and HbA1c were positively related to T2DM （OR=2.11,1.09,P〈0.05） and MIF and TG were positively related to T2DM complicated with CHD （OR=3.95,2.29,P〈0.05）. Conclusion Serum MIF may play an important role in the development of T2DM combined with CHD.