胃起搏治疗胃动力障碍性疾病的临床疗效观察

目的探讨胃肠起搏器治疗胃动力功能障碍性疾病的临床疗效。方法将60例胃动力障碍性疾病患者随机分为起搏器组和西沙比利组2组,前组给予起搏器治疗,1次/日,30分钟/次;后组给予口服西沙比利5mg,3次/天,共20天。治疗前后分别观察症状积分变化,并记录胃电频率、正常及异常胃电节律百分比等胃电参数。结果两组患者治疗前后症状评分比较均有显著性差异,起搏器组在改善嗳气、早饱等症状方面优于西沙比利组(P<0.05),但两组症状总积分比较无显著性差异(P>0.05);两组中除西沙比利组对空腹胃电频率改善不明显外,其它治疗前后比较均有显著性差异(P<0.05);虽然两组治疗后对正常胃电频率百分比均有明显提高(P<0.05或P<0.05),但起搏器组比西沙比利组更明显,两组比较有显著性差异。结论胃肠起搏器可明显改善胃动力功能障碍性疾病的症状及胃电参数变化。

Clinical efficacy of gastrointestinal pacemaker for gastric dynamic dysfunction

Objective To investigate the effect of gastrointestinal pacemaker in treatment of gastric dysfunction.Methods Sixty patients with gastric dynamic dysfunction were randomly divided into two group,pacemaker group(n=30) treated with gastrointestinal pacemaker 30min after meal once daily and cisapride group(n=30) with taking cisapride orally 5mg thrice daily for 20d.Gastric myoelectrical activity was measured and dysfunctional symptoms were evaluated before and after treatment.Result After treatment all the symptoms had been improved and symptom scores were significantly lowered in both groups.The pacemaker group was more significant than cisapride group in improving of belching and early satiety (P<0.05),but there were no significant differences in total symptom scores between two groups (P> 0.05).After treatment, the mean myoelectrical frequency was recovered to normal except the fasting in cisapride group.The percentage of regular gastric myoelectrical frequency was remarkably increased in each group (P<0.05),whereas it was more significant in the pacemaker group than that in cisapride group (P<0.05).Conclusion Gastrointestinal pacemaker can dramatically relieve symptoms and improve the electrogastrography parameters in patients with gastric dynamic dysfunction.