| 大豆异黄酮对Aβ1-42诱导的PC12细胞损伤的保护作用 |
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| 引用本文： | 赵宇红.大豆异黄酮对Aβ1-42诱导的PC12细胞损伤的保护作用[J].中药材,2006,29(1):43-45. |
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| 作者姓名： | 赵宇红 |
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| 作者单位： | 广东药学院,广东,广州,510315 |
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| 摘 要： | 目的:探讨大豆异黄酮提取物对β淀粉样蛋白片段(Aβ1-42)诱导的PC12细胞损伤的保护作用。方法:从大豆中提取并纯化出总异黄酮,通过PC12细胞株体外培养的方法,给予不同剂量的大豆异黄酮预处理,并用10μmol/L Aβ1-42诱导的细胞损伤,检测经处理后细胞MTT及PC12细胞形态的变化。结果:大豆异黄酮可显著降低Aβ1-42诱导的PC12细胞损伤,显著提高细胞的MTT值(P<0.05),并改善细胞的形态,与雌二醇组比较没有显著差异(P>0.05)。结论:大豆异黄酮对Aβ1-42诱导的PC12细胞具有保护作用。
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| 关 键 词： | PC12细胞 大豆异黄酮提取物 β淀粉样蛋白 |
| 文章编号： | 1001-4454(2006)01-0043-03 |
| 收稿时间： | 2005-01-10 |
| 修稿时间： | 2005年1月10日 |
Protection of Soybean Isoflavones to Aβ1-42 Induced Toxic on PC12 Cell |
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| ZHAO Yu-hong.Protection of Soybean Isoflavones to Aβ1-42 Induced Toxic on PC12 Cell[J].Jorunal of Chinese Medicinal Materials,2006,29(1):43-45. |
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| Authors: | ZHAO Yu-hong |
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| Institution: | Guangdong Pharmaceutical College, Guangzhou 510315, China |
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| Abstract: | OBJECTIVE: To explore the effects of the soybean isoflalones to Abeta1-42 induced toxic on PC12 Cell. METHODS: the cell culture PC12 were exposed to 10 micromol/L Abeta1-42 for 24h pertreat with soybean isoflavones for 2hs. The morphololycal and survival of PC12 were observed by MTT. RESULTS: The survival rate of PC12 were decreased after treatment of soybean isoflavones and reshape the morphological of cell. CONCLUSION: Soybean isoflavone has protective effects on PC12 cell. |
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| Keywords: | PC12 cell Soybean isoflavones Amyloid beta |
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