膀胱移行细胞癌环氧化酶-2表达与血管生成的相关性研究

目的探讨环氧化酶-2（COX-2）及微血管密度（MVD）与膀胱移行细胞癌生物学行为的关系及其临床意义。方法采用免疫组化S-P法对103例膀胱移行细胞癌、21例慢性膀胱炎、13例正常膀胱组织标本中COX-2进行检测，同时对上述标本中微血管进行计数。结果膀胱移行细胞癌组织COX-2阳性表达率70．9％，慢性膀胱炎及正常膀胱组织COX-2表达均为阴性。低分化、侵润性、有淋巴转移以及复发癌组织中COX-2阳性表达率显著高于对照组（P〈0．05）。膀胱移行细胞癌组织中MVD与COX-2表达呈正相关（P〈0．05），但COX-2表达及MVD与肿瘤的数量、大小无关（P〉0．05）。结论COX-2表达在膀胱移行细胞癌的发生、发展、转移及复发过程中起重要作用。膀胱移行细胞癌COX-2表达与肿瘤间质微血管的形成密切相关。

Cyclooxygenase-2 expression and tumor interstitial vascular density In transitional cell carcinoma of urinary bladder

Objective To investigate the role of cyclooxygenase-2 (COX-2)and microvascular density (MVD) in the tumorigenesis and progression of transitional cell carcinoma of urinary bladder ( BTCC ), evaluate their clinical significance in BTCC. Methods In this study, immunohistochemistry was used to study COX-2 and the tumor interstitial vascular density in 103 cases of BTCC. And as the contrd, 13 cases of normal bladder tissue and 21 cases of chronic cystitis tissue was collected. At the same time, the numbes of the microvascular were recorded. Results The expression of COX-2 in BTCC was positively correlated to the tumor interstitial vascular density ; Both of them were related to the tumor pathologic grade, the invasiveness of the tumor tissue, the lymphatic transferation and recurrence time of tumor(P＜0.05), but not related to the tumor size or tumor number(P＞0.05). Conclusion COX-2 was overexpressed in BTCC and played an important role in oncogenesis development and recurrence of BTCC. The expression of COX-2 was positively related to the tumormicrovas- cularization.