| 成都地区痢疾杆菌散发、暴发菌株的质粒分析及耐药谱测定 |
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| 引用本文： | 徐荷,陈志新,吕德生,王伯伦.成都地区痢疾杆菌散发、暴发菌株的质粒分析及耐药谱测定[J].四川大学学报(医学版),1992(1). |
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| 作者姓名： | 徐荷 陈志新 吕德生 王伯伦 |
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| 作者单位： | 华西医科大学公共卫生学院流行病学教研室
(徐荷，陈志新，吕德生)，华西医科大学公共卫生学院流行病学教研室(王伯伦) |
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| 摘 要： | 作者对81株散发、暴发痢疾杆菌进行质粒分析和耐药谱测定。结果发现:痢疾杆菌对氨苄青霉素、四环素等耐药率较高,对庆大霉素等敏感。50％的菌株含有质粒,大多数质粒DNA分子量小于6Md,各菌株呈不均一的质粒模式。提示:成都地区痢疾的流行是由许多在遗传学上同源相关性较远的痢疾杆菌引起。通过对暴发菌株所进行的分析可见:1或2株痢疾杆菌导致了此次暴发。质粒分析及耐药谱测定适合于痢疾暴发菌株的鉴定,是痢疾流行病学研究的有用工具。
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| 关 键 词： | 质粒模式 耐药谱 痢疾杆菌 |
Plasmid Analysis and Antibiotic Resistance Pattern Measurement of Shigella in Chengdu |
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| Abstract: | A total of 81 strains of Shigel-la isolated from sporadic cases and casesin an outbreak of Shigella sonnei infectionwas analysed by plasmid profiles and anti-biotic resistance patterns. The strains hada high resistance to ampicillin, tetracyclin,trimethoprim-sulfamethoxazole and chlor-amphenicol; while 97.2% of the strainswere susceptible to gentamicin, kanamycin.The results showed that 50% of the strainsharbored plasmid patterns within each spe-cies, which indicated that many geneti-cally different strains of Shigella were res-ponsible for dysentery epidemics in Cheng-du. According to the results of the plas-mid analysis and antibiotic resistance pat-tern measurement made in the outbreakstrains, it was clearly seen that most ofthe strains were similar or fundamentallysimilar, which suggested that one ortwo strains with genetical homology werethe main causative agent for the outbreak.We think that plasmid profiles and anti-biotic resistance patterns are applicable tothe identification of the outbreak strainsof dysentery as an efficient epidemiologictool. |
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| Keywords: | Plasmid pattern Antibiotic resistance pattern Shigella |
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