Changes in Erythrocyte Membranes during Cold Storage of Whole Blood |
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Authors: | Dr. G.L. Moore R.S. Antonoff D.C. Rau |
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Affiliation: | Biochemistry Division, US Army Medical Research Laboratory, Fort Knox, Ky., USA |
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Abstract: | Abstract. Various assays and physicochemical methods were used to observe changes taking place in membrane proteins from erythrocytes that had been stored up to 42 days at 4°C. Red cell membranes were found to decrease in hydrophobicity, flexibility, and sulfhydryl content on storage. These changes are not due to proteolysis, but related to an unresolved change in the structural characteristics of the lipoproteins comprising the 'membrane superstructure'. |
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