Role of interleukin-18 in host defense against disseminated Candida albicans infection |
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| Authors: | Stuyt Rogier J L Netea Mihai G Verschueren Ineke Fantuzzi Giamila Dinarello Charles A Van Der Meer Jos W M Kullberg Bart Jan |
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| Affiliation: | Department of Medicine, University Medical Center St. Radboud, Nijmegen, The Netherlands. |
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| Abstract: | In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma. |
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