Ferricenium complexes: A new type of water-soluble antitumor agent |
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Authors: | P Köpf-Maier H Köpf E W Neuse |
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Institution: | (1) Institut für Anatomie der Freien Universität Berlin, Königin-Luise-Straße 15, D-1000 Berlin 33;(2) Institut für Anorganische und Analytische Chemie der Technischen Universität Berlin, Straße des 17. Juni 135, D-1000 Berlin 12;(3) Department of Chemistry, University of the Witwatersrand, I Jan Smuts Avenue, 2001 Johannesburg, Republic of South Africa;(4) Abteilung Anatomie der Universität Ulm, D-7900 Ulm |
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Abstract: | Summary The antitumor activity of a series of iron complexes, i.e., of ferrocene Cp2Fe], of tetrachloroferrates(III) R4N]+FeCl4]-, and of ferricenium complexes Cp2Fe]+X- (X-=FeCl4]-, 1/2Cl3FeOFeCl3]2-, H5Mo7O24]-·2H2O, 2,4,6-(NO2)3C6H2O]-, or CCl3COO]-·2 CCl3COOH) was investigated against EAT in CF1 mice. Whereas ferrocene and the ammonium tetrachloroferrates(III) did not show recognizable tumor-inhibiting activity, such activity was exhibited by the water-soluble, salt-like ferricenium complexes; the best antineoplastic properties, with optimum cure rates of 100%, were found for ferricenium picrate and ferricenium trichloroacetate.The ferricenium compounds are the first iron complexes for which antineoplastic activity has now been shown. They represent a new type of antitumor agent insofar as they differ fundamentally from known inorganic and organometallic antitumor agents (a) by their ionic, salt-like character, which is responsible for their high water solubility, and (b) by the absence of a cis-dihalometal moiety; this moiety has been recognized as important for the intracellular action of other known inorganic cytostatics.Abbreviations Cp
C5H5, cyclopentadienyl ring ligand
- EAT
Ehrlich ascites tumor
- IP
intraperitoneal(ly)
- p.t.t.
post transplantationem tumoris
Supported by the Fonds der Chemischen Industrie and by Council, University of the Witwatersrand |
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Keywords: | Iron compounds Ferricenium complexes Antitumor activity Ehrlich ascites tumor |
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