RhoB—mRNA在喉癌中的表达及其临床意义

目的研究RhoB—mRNA在喉癌组织、癌旁组织的表达情况，探讨其与喉癌的发生、发展以及转移之间的关系。方法采用RT-PCR方法检测RhoB—mRNA的表达及分布情况。结果RhoB—mRNA在喉癌组织的表达（2．02±1．157）低于癌旁组织（2．52±1．255）的表达，两组间比较差异有统计学意义（P〈0．05），RhoB—mRNA的表达在喉癌的不同分型、分期之间差异均有统计学意义（P〈0．05），RhoB在喉癌组织中的表达与喉癌的分期呈负相关（r=0．557）。结论RhoB蛋白基因在喉癌的发生、浸润以及淋巴结转移中起抑制作用。

Expression of rho proteins RhoB-mRNA in human laryngeal carcinoma

Objective To study the expression of RhoB-mRNA,and periphery regions in human laryngeal carcinoma.Methods The expression of RhoB-mRNA were examined by RT-PCR method.Results It was noted that the expression of RhoB-mRNA was positively correlated well with the clinical stages.The expression of RhoB-mRNA in carcinoma with node metastasis group was significantly higher than that without node metastasis.The difference between the two groups was statistically significant(P＜0.05).The expression of RhoB-mRNA in different types and stages of laryngeal carcinoma was significantly different(P＜0.05).The expression of RhoB in laryngeal carcinoma negtive correlation with the stages of laryngeal carcinoma(r=0.557).Conclusion The expression of RhoB plays an inhibitive role in the growth,invasion and local node metastasis of human laryngeal carcinoma.RhoB promote the formation,invasion and lymph node metastasis as oncogenes.It may be valuable as predictors for lymph node metastasis and prognosis.