拜阿司匹林、氯吡格雷与那曲肝素三联治疗急性ST段抬高型心肌梗死的临床研究

目的探讨拜阿司匹林、氯吡格雷与那曲肝素三联治疗急性ST段抬高型心肌梗死临床效果。方法选取我院2008年5月至2011年1月收治急性ST段抬高型心肌梗死患者150例,随机分为两组,其中对照组75例,在常规治疗基础上,加用拜阿司匹林、那曲肝素治疗,实验组75例,在对照组治疗基础上,加用氯吡格雷治疗;治疗结束后比较两组患者临床治疗有效率,自发性ST段回落情况,血管再通率及再闭塞率等。结果实验组患者治疗总有效率明显高于对照组患者,组间比较差异有统计学意义(P<0.05);实验组患者自发性ST段完全回落及自发性ST段部分回落发生率均明显高于对照组,组间比较差异均有统计学意义(P<0.05);同时实验组患者血管再通率及血管再闭塞率均明显优于对照组,组间比较差异有统计学意义(P<0.05)。结论拜阿司匹林、氯吡格雷与那曲肝素三联治疗急性ST段抬高型心肌梗死临床效果确切,能够显著改善临床症状、体征,具有临床推广使用价值。

The Clinical Study of Clopidogrel plus Aspirin and Low Molecular Heparin on ST-Elevation Acute Myocardial Infarction

Objective To investigate therapeutic effect of clopidogrel plus aspirin and low molecular heparin on ST-elevation acute myocardial infarction. Methods 150 patients with ST-elevation acute myocardial infarction were chose in the period from May 2008 to January 2011 in our hospital and randomly divided into two groups including control group （75 patients） with aspirin and low molecular heparin treatment and experimental group （75 patients） with clopidogrel treatment on the basis of control groups treatment; and after treatment the total effective rate, the situation of spontaneous ST-segment downing, the recanalization rate and the re-occlusion rate of both groups were compared. Results The total effective rate of experimental group were significantly better than control group（P〈0.05）. The wholly and partly spontaneous ST-segment downing rate of experimental group were significantly better than control group（P〈0.05）. And the recanalization rate and the re-occlusion rate of experimental group were also significantly better than control group（P〈0.05）. Conclusion The clopidogrel plus aspirin and low molecular heparin on ST-elevation acute myocardial infarction obtain excellent effect, can effectively improve the symptoms and signs, and is worthy of clinical application.