| 阿维A联合窄谱中波紫外线治疗寻常型银屑病疗效观察及血清透明质酸的测定 |
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| 引用本文： | 周敏,丰世科,陈金,段西凌,陈琦,陈学军. 阿维A联合窄谱中波紫外线治疗寻常型银屑病疗效观察及血清透明质酸的测定[J]. 四川医学, 2009, 30(7): 1002-1003 |
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| 作者姓名： | 周敏 丰世科 陈金 段西凌 陈琦 陈学军 |
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| 作者单位： | 四川省人民医院皮肤病性病研究所,四川,成都,610031;四川省人民医院皮肤病性病研究所,四川,成都,610031;四川省人民医院皮肤病性病研究所,四川,成都,610031;四川省人民医院皮肤病性病研究所,四川,成都,610031;四川省人民医院皮肤病性病研究所,四川,成都,610031;四川省人民医院皮肤病性病研究所,四川,成都,610031 |
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| 基金项目： | 四川省卫生厅科研项目 |
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| 摘 要： | 目的观察阿维A联合NB-UVB治疗寻常型银屑病的疗效及治疗前后血清透明质酸的变化。方法40例寻常型银屑病患者给予阿维A口服及NB-UVB照射治疗，NB．UVB照射每周3次，共20次，观察临床疗效及不良反应并测定治疗前后患者血清透明质酸水平。结果治疗总有效率为92．5％。治疗前透明质酸水平较正常人对照者增高，治疗后下降，其差异具有统计学意义（P〈0．05）。结论阿维A与NB-UVB联合治疗寻常型银屑病有较好疗效，可降低血清透明质酸水平。
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| 关 键 词： | 寻常型银屑病 窄谱中波紫外线 阿维A 透明质酸 |
Observation of clinical effect and changes of serum hyaluronic acid in psoriastic patients treated with etretinate and narrow-band ultraviolet B |
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| Affiliation: | ZHOU Min,FENG Shi-ke, CHEN Jin, et al. (Iastitute of Dermatology, The People＇s Hospital of Sichuan , Chengdu , Sichuan 610031, China ) |
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| Abstract: | Objective To observe the therapeutic efficacy of etretinate and narrow-band ultraviolet B(NB-UVB)for pso-fie.sis and to investigate the changes of hyaluronic acid in serum. Methods 40 cases of psoriasis vulgaris were treated with etreti-hate and NB-UVB irradiation which was performed 3 times a week ,totally for 20 times. The clinical efficacy and adverse reactions were observed and serum hyalurunic acid level were measured before and after treatment in patients. Results The total clinical efficiency was 92.5%. The level of hyaluronic acid in serum decreased after treatment which was higher than normal controls be-fore treatment. The difference was statistically significant(P<0.05). Conclusion Etretinate and NB-UVB show a good effect on treatment of psoriasis uulgaris and can reduce the level of serum hyaluronic acid. |
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| Keywords: | psoriasis vulgaris narrow-band ultraviolet B etretinate hyaluronic acid |
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