首页 | 本学科首页   官方微博 | 高级检索  
     


The utility of PET/CT with 68Ga-DOTATOC in sarcoidosis: comparison with 67Ga-scintigraphy
Authors:Tomomi Nobashi  Yuji Nakamoto  Takeshi Kubo  Takayoshi Ishimori  Tomohiro Handa  Kiminobu Tanizawa  Kohei Sano  Michiaki Mishima  Kaori Togashi
Affiliation:1.Department of Diagnostic Imaging and Nuclear Medicine,Kyoto University Graduate School of Medicine,Kyoto,Japan;2.Department of Respiratory Medicine,Kyoto University Graduate School of Medicine,Kyoto,Japan;3.Department of Respiratory Care and Sleep Control Medicine,Kyoto University Graduate School of Medicine,Kyoto,Japan
Abstract:

Objective

This study was designed to compare the clinical efficacy of 68Ga-DOTA-Tyr-octreotide (DOTATOC)-positron emission tomography (PET)/computed tomography (CT) with that of conventional 67Ga-scintigraphy (GS), and to correlate quantitative parameters on DOTATOC-PET/CT with clinical data, in patients with sarcoidosis.

Methods

Twenty patients who were histologically and/or clinically diagnosed with sarcoidosis and underwent both DOTATOC-PET/CT and GS were analyzed in this study. The numbers of patients with positive findings for each organ were determined. The total numbers of involved nodal areas in the chest, as determined by DOTATOC-PET and gallium single-photon emission tomography (Ga-SPECT), were compared. The correlations between quantitative parameters on PET and clinical laboratory data were evaluated.

Results

DOTATOC-PET/CT was positive in 19 patients, being negative in only one patient with chronic inactive sarcoidosis, whereas GS was positive in 17 patients. DOTATOC-PET/CT visualized more lesions in lymph nodes, uvea, and muscles than did Ga-scintigraphy and identified more involved areas than did GS-SPECT (p < 0.0001). Whole-body active lesion volume showed a significant, but moderate correlation with angiotensin-converting enzyme level (ρ = 0.64, p = 0.0044).

Conclusions

PET/CT with DOTATOC may be superior to conventional GS in detecting sarcoidosis lesions, especially in lymph nodes, uvea, and muscles. Volumetric parameters in DOTATOC-PET/CT may be helpful in estimating the activity of sarcoidosis.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号