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| 藿香正气口服液中3个活性成分的UPLC法测定 | |
| 引用本文： | 邓开英,余佳文,彭涛,夏永鹏,邱宗荫. 藿香正气口服液中3个活性成分的UPLC法测定[J]. 中国医药工业杂志, 2012, 43(9): 780-782 |
| 作者姓名： | 邓开英 余佳文 彭涛 夏永鹏 邱宗荫 |
| 作者单位： | 1. 重庆医科大学,重庆400016;重庆市食品药品检验所,重庆401121 2. 太极集团重庆涪陵制药厂有限公司,重庆,408000 3. 重庆市卫生局,重庆,401147 4. 重庆医科大学,重庆,400016 |
| 摘 要： | 建立了超高效液相色谱法同时测定藿香正气口服液中的橙皮苷、和厚朴酚及厚朴酚。采用C18色谱柱,以乙腈-0.05%磷酸为流动相,梯度洗脱,检测波长为220 nm。橙皮苷、和厚朴酚与厚朴酚分别在6.4～128 ng、3.2～64 ng和6.4～128 ng范围内线性关系良好,平均回收率分别为98.3%、98.4%和102.2%,RSD分别为0.5%、0.9%和2.0%。10批样品测定结果与中国药典HPLC方法测定结果一致。 |
| 关 键 词： | 藿香正气口服液 橙皮苷 和厚朴酚 厚朴酚 超高效液相色谱 测定 |
Determination of Three Active Ingredients in Huoxiang Zhengqi Oral Liquid by UPLC |
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| DENG Kaiying , YU Jiawen , PENG Tao , XIA Yongpeng , QIU Zongyin. Determination of Three Active Ingredients in Huoxiang Zhengqi Oral Liquid by UPLC[J]. , 2012, 43(9): 780-782 | |
| Authors: | DENG Kaiying YU Jiawen PENG Tao XIA Yongpeng QIU Zongyin |
| Affiliation: | 1(1.Chongqing Medical University,Chongqing 400016;2.Chongqing Institute of Food and Drug for Control,Chongqing 401121; 3.Chongqing Fuling Pharmaceutical Co.,Ltd.,Taiji Group,Chongqing 408000;4.Chongqing Municipal Health Bureau,Chongqing 401147) |
| Abstract: | An UPLC method was established for the determination of hesperidin,honokiol and magnolol in Huoxiang Zhengqi oral liquid.A C18 column was used with the mobile phase of acetonitrile-0.05% phosphoric acid by gradient elution at the detection wavelength of 220 nm.The calibration curves were linear in the ranges of 6.4-128 ng,3.2-64 ng and 6.4-128 ng,respectively.The average recoveries were 98.3%,98.4% and 102.2%,with RSDs of 0.5%, 0.9% and 2.0%,respectively.The results for 10 batches of sample were consistent with those by HPLC in Chinese Pharmacopoeia. |
| Keywords: | Huoxiang Zhengqi oral liquid hesperidin honokiol magnolol UPLC determination |
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