Cardiorespiratory Fitness and Metabolic Syndrome in Older Men and Women: The Dose Responses to Exercise Training (DR's EXTRA) study |
| |
| Authors: | Maija Hassinen Timo A. Lakka Leena Hakola Kai Savonen Pirjo Komulainen Hannu Litmanen Vesa Kiviniemi Reija Kouki Harri Heikkil�� Rainer Rauramaa |
| |
| Affiliation: | 1Kuopio Research Institute of Exercise Medicine, Kuopio, Finland; ;2Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland; ;3Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland; ;4Information Technology Centre, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. |
| |
| Abstract: | OBJECTIVEWe studied the association of maximum oxygen uptake (Vo2max) with the development and resolution of metabolic syndrome (MetS) for 2 years in older individuals.RESEARCH DESIGN AND METHODSSubjects were a population sample of 1,226 men and women aged 57–78 years. We assessed Vo2max directly by respiratory gas analysis during maximum exercise testing and used dichotomous and continuous variables for MetS.RESULTSOne SD increase in baseline Vo2max associated with 44% (95% CI 24–58) decreased risk of developing MetS. Individuals in the highest third of baseline Vo2max were 68% (37–84) less likely to develop MetS than those in the lowest third. One SD increase in Vo2max increased the likelihood to resolve MetS 1.8 (1.2–2.8) times. Individuals in the highest Vo2max third were 3.9 (1.5–9.9) times more likely to resolve MetS than those in the lowest third.CONCLUSIONSHigher levels of cardiorespiratory fitness protect against MetS and may resolve it in older individuals.Cross-sectional population studies have shown an inverse association between cardiorespiratory fitness (CRF) and the metabolic syndrome (MetS) in middle-aged and older men and women (1,2). There are few prospective population studies on the association between CRF and the development of MetS (3–6) and no such studies on the resolution of MetS. None of these studies have been conducted in older men and women. Evidence of the association between changes in CRF and metabolic risk rely on relatively small prospective studies among middle-aged or high-risk individuals (6,7). We therefore studied the association of maximum oxygen uptake (Vo2max) with the development and resolution of MetS and changes in Vo2max and metabolic risk in a population sample of older men and women. |
| |
| Keywords: | |
|
|
