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Pathological Complete Remission of Advanced Hepatocellular Carcinoma with Main Portal Vein Tumor Thrombosis by Hepatic Arterial Infusion Chemotherapy |
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| Authors: | Yong Gil Kim Jong Ryul Eun Tae Nyeun Kim Heon Ju Lee Jae Woon Kim Jay Chun Chang Sung Su Yun Joon Hyuk Choi |
| Affiliation: | *Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.;†Department of Radiology, Yeungnam University College of Medicine, Daegu, Korea.;‡Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea.;§Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea. |
| Abstract: | Cures for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are rare and difficult. We report a case of pathologically confirmed complete remission of HCC induced by hepatic arterial infusion chemotherapy (HAIC). A 45-year-old male patient had a massive HCC in the right lobe of the liver and tumor thrombus in the right and main portal veins. He achieved a partial response after two cycles of HAIC with 5-fluorouracil (750 mg/m2) and cisplatin (25 mg/m2). After the completion of six cycles he received a curative partial hepatectomy, and histopathology revealed complete necrosis without any viable tumor cell. He was in good health at a 4-month follow-up. These results suggest that this regimen is a promising therapeutic modality for the treatment of advanced HCC with PVTT. |
| Keywords: | Hepatocellular carcinoma Portal vein tumor thrombosis Chemotherapy 5-fluorouracil Complete remission |