曲普瑞林联合腹腔镜保守手术治疗子宫内膜异位症的疗效观察

目的：探讨曲普瑞林联合腹腔镜保守手术治疗子宫内膜异位症的疗效观察。方法：82例子宫内膜异位症患者分为联合组与对照组。两组患者均予以腹腔镜保守手术治疗,联合组术后予以曲普瑞林3.75mg肌注,每月1次,连用6个月。观察并比较两组患者治疗前后性激素水平的变化、治疗结束后随访6个月的治疗效果、1年内怀孕情况及不良反应情况。结果：治疗6个月后,两组患者性激素FSH、LH、E2水平均较治疗前下降（P〈0.05或P〈0.01）,且联合组下降幅度明显优于对照组（P〈0.05）;治疗结束后随访6个月,联合组患者的临床疗效明显优于对照组,复发率明显低于对照组（χ^2=5.14,P〈0.05）;停药1年后,联合组患者的成功怀孕率明显高于对照组（χ^2=4.02,P〈0.05）,两组患者治疗期间不良反应发生率比较无明显统计学差异（P〉0.05）。结论：曲普瑞林联合腹腔镜保守手术治疗子宫内膜异位症可以取得较单纯手术治疗更好的疗效,降低术后复发率,提高怀孕率,不良反应少。

Triptorelin combined with laparoscopic surgery in the treatment of endometriosis

Objectives：To discuss the curative effect of Triptorelin combined with laparoscopic surgery in the treatment of endometriosis.Method：82 patients with endometriosis were randomly divided into the treatment group and the control group.The patients in 2 group were both given the laparoscopic surgery,while the patients in the treatment group were additionally given 3.75mg Triptorelin intramuscular injection once a month for 6 months.The changes of sex hormone levels of patients in two groups were observed and compared before and after treatment.Results：The 6 hormone（FSH,LH,E2） levels of patients in 2 groups declined six months after treatment（P〈0.05 or P〈0.01）,and the declining rate in the treatment group was much better than that in the control group（P〈0.05）.As for the 6 months＇ follow- up after the treatment,the curative effect of the treatment group was much better than that of the control group,and the reoccurrence rate was much lower than that of the control group（χ^2= 5.14,P 〈0.05）.After one year＇s drug withdrawal,the successful pregnancy rate of patients in the treatment group was much higher than that in the control group（χ^2= 4.02,P〈0.05）.After comparing the untoward effect rates of patients in 2 groups during treatment,there was no significant statistical difference（P〉0.05）.Conclusion：Triptorelin combined with laparoscopic surgery has reliable effect on endometriosis,which can reduce the postoperative reoccurrence rate and increase the pregnancy rate with less untoward effect.