Rho关联含卷曲螺旋蛋白激酶1的表达与老年慢性阻塞性肺疾病并发肺动脉高压患者肺动脉压的相关性

目的探讨Rho关联含卷曲螺旋蛋白激酶1(ROCK1)的表达与老年慢性阻塞性肺疾病(COPD)并发肺动脉高压(PHT)患者肺动脉压(PAP)的相关性。方法 78例COPD患者依据患者是否并发PHT分为观察组(COPD并发PHT组)38例和对照组(单纯COPD组)40例,比较2组患者PAP、ROCK1、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平,并对ROCK1水平与COPD并发PHT患者PAP的相关性进行分析。结果观察组患者PAP、单核细胞ROCK1及血清ROCK1、TNF-α、CRP水平显著高于对照组,差异均有统计学意义(P<0.001)。COPD并发PHT患者的血清和单核细胞ROCK1水平与PAP呈正相关(P<0.001)。结论血清和单核细胞内ROCK1表达升高可能与COPD患者出现PHT有关,ROCK1可以作为干预COPD向PHT进展的新靶点。

Correlation between Rho associated coiled coil forming protein kinase 1 and pulmonary arterial pressure in patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension

Objective To study the correlation between Rho associated coiled coil forming protein kinase 1（ ROCK1） and pulmonary arterial pressure（ PAP） in patients with chronic obstructive pulmonary disease（ COPD） complicated with pulmonary hypertension（ PHT）. Methods Seventy-eight patients with COPD were divided into observation group（ COPD complicated with PHT group,n = 38） and control group（ simple COPD group,n = 40） according to whether complicated with PHT. The levels of PAP,ROCK1,tumor necrosis factor α（ TNF-α） and C-reactive protein（ CRP） were compared between the two groups. The correlation between ROCK1 and PAP in patients with COPD and PHT was analyzed. Results The levels of PAP,ROCK1 in monocyte and serum,TNF-α and CRP in observation group were significantly higher than those in control group（ P〈0. 001）. The ROCK1 level in serum and monocyte was positively correlated to PAP in patients with COPD complicated with PHT. Conclusion The high expression of ROCK1 in serum and monocyte may play a key role in the development of PHT in COPD patients.