卡介菌多糖核酸联合泛昔洛韦治疗复发性生殖器疱疹的疗效及预防复发作用

目的：探讨卡介菌多糖核酸联合泛昔洛韦治疗复发性生殖器疱疹的疗效及预防复发作用。方法：选择70例复发性生殖器疱疹随机分为两组（对照组与联合组）。两组均予以口服泛昔洛韦片0.25g,2次/d,连用10d;后改为0.125g,2次/d,整个疗程共3个月。联合组在此基础上予以卡介菌多糖核酸1mL肌注,2次/周,连用3个月。对照组患者仅予以口服泛昔洛韦,剂量及疗程同联合组。观察两组患者治疗后临床效果及药物不良反应,并随访治疗结束后半年及1年内的复发率。结果：联合组治疗后临床总有效率为77.14%,明显高于对照组的42.86%（χ^2=8.57,P〈0.01）。联合组和对照组治疗期间出现药物不良反应6例和4例,症状均较轻,两组比较无统计学差异（χ^2=0.47,P〉0.05）。治疗结束后对治疗有效者均随访半年及1年内的复发率,联合组的复发率均明显低于对照组（P〈0.05或P〈0.01）。结论：卡介菌多糖核酸联合泛昔洛韦治疗复发性生殖器疱疹取得了较好效果,不良反应轻,并可降低其复发率,具有治疗和预防复发双重作用。

Application of BCG- PSN combined with Famciclovir in the treatment of RGH

Objectives：To discuss the curative effect and reoccurrence prevention of BCG- PSN combined with Famciclovir on the treatment of Recurrent Genital Herpes（RGH）.Method：70 cases of patients with RGH were selected and divided into the control group and the experiment group randomly.All the patients were given Famciclovir tablets for 0.25g twice a day for 10 days.For the next course of 3 months,the dosage was changed to 0.125g twice a day.The patients of the experiment group were additionally given 1mL of BCG- PSN by intramuscular injection twice a week for 3 months,while the patients in the control group only took Famciclovir with the same dosage orally.The clinical curative effect,drug adverse reaction,half- a- year reoccurrence rate and one- year reoccurrence rate of the patients in the 2 groups were observed and compared after the treatment.Results：The total clinical efficiency rate of patients in the combined group was 77.14%,which was much higher than that（42.86 %） in control group（χ^2= 8.57,P 〈0.01）.There were 6 and 4 cases showing adverse reactions in experiment group and control group respectively,with no statistical differences（χ^2= 0.47,P〉0.05）.The reoccurrence rate of patients in the experiment group was much lower than that in control group（P〈0.05 or P〈0.01）.Conclusion：BCG- PSN combined with Famciclovir has reliable curative effect on the treatment of recurrent Genital Herpes（RGH）.It produces less adverse reactions and low reoccurrence rate.