水泡状胎块中p57、p53及Ki-67的表达及意义 |
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引用本文: | 陈昊宾 孙昆昆 戴林等. 水泡状胎块中p57、p53及Ki-67的表达及意义[J]. 中国性科学, 2014, 0(4): 26-30 |
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作者姓名: | 陈昊宾 孙昆昆 戴林等 |
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作者单位: | [1]曲靖市第一人民医院病理科,云南曲靖655000; [2]北京大学人民医院病理科,北京100036 |
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摘 要: | 目的:探讨p57、p53和Ki-67的表达在水泡状胎块病理诊断与鉴别诊断中的作用和意义。方法:应用SP法检测74例完全性水泡状胎块(complete hydatidiform mole,CHM)、72例部分性水泡状胎块(partial hydatidiform mole,PHM)和79例水肿性流产胎(hydropic abortion,HA)三组病变组织中p57、p53和Ki-67的表达情况,以正常成熟胎盘(normal mature placenta,NMP)10例为正常对照。同时分析患者的年龄及血中HCG浓度在鉴别各组疾病中的价值。结果:p57在CHM组中的表达明显低于PHM组、HA组及NMP组(P〈0.01);p53和Ki-67在PHM组和CHM组的阳性表达高于HA及NMP组(P〈0.05)。完全性水泡状胎块的发病高峰在21~25岁,部分性水泡状胎块发病高峰在25~30岁,水肿性流产胎发病高峰在30~35岁。PHM组患者血中β-HCG含量高于CHM组,CHM组又高于HA组。结论:Ki-67和p53的表达对于鉴别水泡状胎块与流产水肿绒毛有重要价值,但对于区别完全性与部分性水泡状胎块其价值有限;而p57蛋白在CHM和PHM的表达和分布有明显差异,可作为水泡状胎块分型诊断的客观辅助指标。HA、PHM和CHM的发病高峰在不同的年龄阶段,可作为辅助鉴别诊断的参考。患者血中HCG的浓度是鉴别水泡状胎块与水肿性流产胎重要的临床客观辅助指标。
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关 键 词: | 水泡状胎块 完全性 部分性 水肿性流产胎 p57 p53 Ki-67免疫组织化学 年龄 β-HCG |
Expression of gene p57,p53 and Ki- 67 in hydatidiform moles |
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Affiliation: | CHEN Haobin, SUN Kunkun, DAI Lin, CHEN Yunxin, HUANG Shaohua.( 1. Department of Pathology, First People' s Hospital of Qujing, Qujing, 655000, China; 2. Department of Pathology, Peking University People's Hospital, Beijing 100036, China) |
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Abstract: | Objectives:To study the expression of gene p57,p53 and Ki-67 in hydatidiform moles and their effects on differential diagnosis of complete hydatidiform moles(CHM) from partial hydatidiform moles(PHM) and hydropic abortions(HA).Method:74 cases of CHM,72 PHM and 79 HA were evaluated by immunohistochemistry of formalin- fixed tissues using a monoclonal antibody against p57,p53 and Ki- 67 protein,while 10 normal mature placentas(NMP) were selected as the control group.Results:In all 72 cases of PHM,79 HA and 10 NMP,nuclear p57 was strongly expressed.In CHM,p57 expression was absent.Expression of p53 and Ki- 67 in HM was stronger than in HA.Conclusion:The immunohistochemical analysis for p57 expression is a useful tool for the differential diagnosis to distinguish CHM from PHM and HA.Ki- 67 and p53 are useful tools to distinguish HA from HM. |
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Keywords: | Hydatidiform moles Complete Partial p57 P53 Ki-67 Immunohistochemistry Age β-HCG |
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