2型糖尿病家系一级亲属脂代谢紊乱和胰岛素抵抗变化的研究

目的　探讨 2型糖尿病家系一级亲属非糖尿病同胞脂代谢紊乱和胰岛素抵抗的情况。方法　检测了 5 2例 2型糖尿病家系一级亲属非糖尿病同胞 (FDR)和 19例正常对照组的体重指数、腰围、臀围、腰臀比、血压、血糖、血脂和胰岛素水平。采用稳态模式 (HOMA IR)评价胰岛素抵抗。结果　FDR组的腰围 (W )、臀围 (H)、体重指数(BMI)、空腹胰岛素 (FINS)和HOMA IR明显高于对照组 (P <0 .0 1)。多元逐步回归分析显示 ,空腹血糖 (FBG)、BMI和家族史是影响 2型糖尿病家系一级亲属非糖尿病同胞胰岛素抵抗主要的危险因素。结论　 2型糖尿病家系一级亲属非糖尿病同胞在未发生糖尿病时已存在高胰岛素血症和胰岛素抵抗 ,并且可能与遗传有关

Study on dyslipidemia and insulin resistance of non-diabetic first degree relatives of type 2 diabetes

Objective To investigate dyslipidemia and insulin resistance in nondiabetic first degree relatives of type 2 diabetes mellitus.Methods The anthropometrical parameters,blood pressure,blood glucose,serum lipid and serum insulin were analyzed in 52 non-diabetic first degree relatives of type 2 diabetes (FDR) and 19 control subjects.Homeostasis model assessment(HOMA-IR) was applied to assess the status of insulin resistance.Results The levels of waist circumference,hip,body mass index(BMI),fasting insulin(FINS) and HOMA-IR were significantly elevated in FDR compared with control.Multiple stepwise regression showed that fasting blood glucose (FBG),BMI and family history of diabetes were the major risk factors affecting insulin resistance in FDR.Conclusion Hyperinsulinemia and insulin resistance had appeared before the development of diabetes,and it may be relative to heredity.