| 有机羧酸氧钒配合物的合成及其抗糖尿病活性 |
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| 引用本文： | 谢明进,刘伟平,杨懿昆,普绍平,李玲,杨丽川,陈植和. 有机羧酸氧钒配合物的合成及其抗糖尿病活性[J]. 中国药物化学杂志, 2001, 11(3): 134-137 |
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| 作者姓名： | 谢明进 刘伟平 杨懿昆 普绍平 李玲 杨丽川 陈植和 |
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| 作者单位： | 1. 昆明贵金属研究所,
2. 昆明医学院 |
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| 基金项目： | 云南省应用基础研究基金资助项目(98C107M) |
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| 摘 要： | 合成了苯甲酸氧钒(1)、丙二酸氧钒钠(2)、阿司匹林氧钒(3)、3,5-二异丙基水杨酸氧钒(4)、酒石酸氧钒(5)和乙酰丙酮氧钒(6)6个新型的有机羧酸氧钒配合物，其中3个未见文献报道。运用元素分析、红外光谱、紫外光谱、质谱和核磁共振氢谱对所合成配合物的结构进行了初步确证。在实验性动物模型上研究了这些配合物的初步毒性和降血糖作用。结果表明酒石酸氧钒和乙酰丙酮氧钒具有活性高、安全性好的优点，显示出潜在的应用前景。
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| 关 键 词： | 有机羧酸氧钒配合物；合成；结构；降血糖活性 |
| 文章编号： | 1005-0108(2001)03-0134-04 |
| 修稿时间： | 2001-02-20 |
Synthesis andAnti-diabetic Activity of Several Organically Carboxylate Oxovanadium CoordinationCompounds |
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| XIE Ming-jin,LIU Wei-ping,YANG Yi-kun,PU Shao-ping,LI Ling,YANG Li-chuan,CHEN Zhi-he. Synthesis andAnti-diabetic Activity of Several Organically Carboxylate Oxovanadium CoordinationCompounds[J]. Chinese Journal of Medicinal Chemistry, 2001, 11(3): 134-137 |
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| Authors: | XIE Ming-jin LIU Wei-ping YANG Yi-kun PU Shao-ping LI Ling YANG Li-chuan CHEN Zhi-he |
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| Affiliation: | XIE Ming-jin 1,LIU Wei-ping 1,YANG Yi-kun 1,PU Shao-ping 1,LI Ling 2,YANG Li-chuan 2,CHEN Zhi-he 2 |
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| Abstract: | Six organically carboxylate oxovanadium coordination compounds were synthesized and their chemical structures were determined by elemental analysis,IR,UV,MS, 1H-NMR.These compounds were submitted for the test of preliminary toxicity and anti-diabetic activity in mice.The results showed that VO(tart) 2 and VO(acac) 2 were safe and could significantly lower the glucose level in the blood of mice,exhibiting greater anti-diabetic activity than VOSO 4 and NH 4VO 3. |
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| Keywords: | organically carboxylate oxovanadium coordination compounds synthesis structure anti-diabetic activity |
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