Neurophysiological and psychological predictors of genetic risk for schizophrenia |
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| Authors: | Vladimir Trubnikov Lubov Uvarova Margarita Alfimova Vera Orlova Natalia Ozerova Nickolai Abrosimov |
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| Affiliation: | (1) Prophylactic Psychiatry Research Institute, National Mental Health Research Center, Academy of Medical Sciences Russia, Zagorodnoe shosse 2, 113152 Moscow, Russia |
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| Abstract: | Mathematical genetic analyses were performed on a sample of schizophrenic families (25 probands and 58 first-degree relatives). Heritability coefficients were estimated for EEG power spectrum parameters and their topography, and also for psychological test data on thought and speech process disorder, designed to assess altered selectivity in cognitive activity. Multiple regression equations for genetic counseling regarding the prognosis of mental illness were derived from the neurophysiological and psychological measures. |
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| Keywords: | Heritability computer EEG topography psychology schizophrenia multiple regression |
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